Pharmacokinetics in clinical practice. I. Concepts

JAMA. 1976 Apr 26;235(17):1864-7.

Abstract

Important concepts of pharmacokinetics, such as the biologic half-life, clearance, and bioavailability of drugs, can be utilized to describe and predict the time course of drug concentrations in plasma as a function of dose and frequency of drug administration. In quantitative terms, they can serve to characterize the individuality of the patient, including the effects of disease, with respect to drug absorption, distribution, excretion, and metabolism.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Biological Availability
  • Biotransformation
  • Half-Life
  • Humans
  • Injections, Intravenous
  • Kidney / metabolism
  • Liver / metabolism
  • Metabolic Clearance Rate
  • Pharmaceutical Preparations / administration & dosage
  • Pharmaceutical Preparations / blood
  • Pharmaceutical Preparations / metabolism*

Substances

  • Pharmaceutical Preparations