The Epigenetic Link between Polyphenols, Aging and Age-Related Diseases

Genes (Basel). 2020 Sep 18;11(9):1094. doi: 10.3390/genes11091094.

Abstract

Aging is a complex process mainly categorized by a decline in tissue, cells and organ function and an increased risk of mortality. Recent studies have provided evidence that suggests a strong association between epigenetic mechanisms throughout an organism's lifespan and age-related disease progression. Epigenetics is considered an evolving field and regulates the genetic code at several levels. Among these are DNA changes, which include modifications to DNA methylation state, histone changes, which include modifications of methylation, acetylation, ubiquitination and phosphorylation of histones, and non-coding RNA changes. As a result, these epigenetic modifications are vital targets for potential therapeutic interventions against age-related deterioration and disease progression. Dietary polyphenols play a key role in modulating these modifications thereby delaying aging and extending longevity. In this review, we summarize recent advancements linking epigenetics, polyphenols and aging as well as critical findings related to the various dietary polyphenols in different fruits and vegetables. In addition, we cover studies that relate polyphenols and their epigenetic effects to various aging-related diseases such as cardiovascular diseases, neurodegenerative diseases, autoimmune disorders, diabetes, osteoporosis and cancer.

Keywords: DNA methylation; aging; histone modifications; non-coding RNAs and polyphenols.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aging / drug effects*
  • Animals
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / pathology
  • Cardiovascular Diseases / prevention & control*
  • DNA Methylation*
  • Epigenesis, Genetic*
  • Gene Expression Regulation
  • Humans
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Neoplasms / prevention & control*
  • Neurodegenerative Diseases / genetics
  • Neurodegenerative Diseases / pathology
  • Neurodegenerative Diseases / prevention & control*
  • Polyphenols / therapeutic use*

Substances

  • Polyphenols