Abstract
Prostaglandin E(2) (PGE(2)) is a major prostanoid with a wide variety of biological activities. PGE(2) can influence blood pressure (BP) both positively and negatively. In particular, centrally administered PGE(2) induces hypertension whereas systemic administration of PGE(2) produces a hypotensive effect. These physiologically opposing effects are generated by the existence of multiple EP receptors, namely EP(1-4), which are G protein-coupled receptors with distinct signaling properties. This review highlights the distinct roles of PGE(2) in BP regulation and the involvement of specific EP receptor subtypes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Blood Pressure / drug effects*
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Dinoprostone / pharmacology*
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Dinoprostone / physiology*
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Humans
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Kidney / blood supply
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Kidney / drug effects
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Kidney / innervation
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Receptors, Prostaglandin E / physiology
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Receptors, Prostaglandin E, EP2 Subtype / drug effects
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Receptors, Prostaglandin E, EP2 Subtype / physiology
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Receptors, Prostaglandin E, EP3 Subtype / drug effects
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Receptors, Prostaglandin E, EP3 Subtype / physiology
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Receptors, Prostaglandin E, EP4 Subtype / drug effects
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Receptors, Prostaglandin E, EP4 Subtype / physiology
Substances
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Receptors, Prostaglandin E
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Receptors, Prostaglandin E, EP2 Subtype
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Receptors, Prostaglandin E, EP3 Subtype
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Receptors, Prostaglandin E, EP4 Subtype
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Dinoprostone