[Effect of vitamin K on bone material properties]

Clin Calcium. 2009 Dec;19(12):1797-804.
[Article in Japanese]

Abstract

Collagen cross-links are determinants of bone quality. Because vitamin K is thought to ameliorate bone quality, we summarized the literature regarding the effect of vitamin K such as menatetorenone (MK-4) on bone matrix property in the review. MK-4 seems to stimulate the osteoblastic activity. This results in the increase in collagen accumulation and lysyl oxidase controlled enzymatic cross-links in bone. Furthermore, vitamin K stimulates the secretion of collagen binding protein regulating proper fibrillogenesis such as leucine-rich repeat protein (tsukushi). This kinds of non-collagenous proteins induced by the treatment of vitamin K may also affect proper collagen cross-link formation and show the favorable effect on bone material quality.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Matrix / enzymology
  • Bone Matrix / metabolism*
  • Collagen / metabolism*
  • Diabetes Mellitus / metabolism
  • Humans
  • Leucine-Rich Repeat Proteins
  • Osteoblasts / physiology
  • Osteoporosis / drug therapy
  • Osteoporosis / metabolism
  • Protein-Lysine 6-Oxidase / physiology
  • Proteins / metabolism
  • Stimulation, Chemical
  • Vitamin K 2 / pharmacology*
  • Vitamin K 2 / therapeutic use

Substances

  • Leucine-Rich Repeat Proteins
  • Proteins
  • Vitamin K 2
  • Collagen
  • Protein-Lysine 6-Oxidase